Friday, April 18, 2014

Liposomes have numerous uses as biochemical and biophysical tools: as vehicles for the delivery of both water and of oil-soluble materials to the cell; as immunological adjuvants; as substrates for the study of membrane properties such as rotational or translational diffusion in the plane of the membrane; and as intermediates in the construction of bilayers large enough for the study of electrical properties of membranes.
Liposomes Lipid Vesicles Liposome Formulations 73 150x150

Many of the interactions studied in the biological and biomedical sciences occur with receptors at cell membrane surfaces. Prominent examples are neurotransmitters, cytokine receptors, tyrosine kinase receptors, ligang-and voltage-gated ion channels, G protein-coupled receptors, and antibody receptors. Interactions with these receptors are of special importance not only to academics, but also to the pharmaceutical industry as almost half of the 100 best-selling drugs on the market are targeted to a membrane receptor. More than 50% of current drug targets are membrane bound.Naturally, there is a great interest in development of sensors using membrane proteins for drug discovery and high-throughput screening for detection of pathogens/toxins. This book describes protocols to array individual, intact small unilamellar vesicles (liposomes) onto chemically modified microwell substrates. These arrays can be used as biosensors using membrane proteins or receptors incorporated in the lipid bilayer of the arrayed liposomes. One of the key examples covered in this work is the use of this platform to display GM1 ganglioside receptor to detect cholera toxin in analyte solutions.

Novel Biosensors Using Intact Liposome Microarrays: Concept, Design, Fabrication and Testing of Membrane Protein and Receptor Based Biosensors

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Build Biotech Wealth on Solid Platforms Grant Zeng CountingPips Blog

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Build Biotech Wealth on Solid Platforms: Grant ZengCountingPips (blog)Bio-Path's pipeline also includes liposomal Bcl-2, a liposome-delivered antisense cancer drug that targets the lymphoma and certain solid tumor markets, which could enter clinical trials in 2014. For both Arrowhead and Bio-Path, I like their respective ... Read the full story: Build Biotech Wealth on Solid Platforms: [...]

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Liposome Technology, Second Edition, Volume II: Entrapment Of

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Liposome Technology, Second Edition, is an updated, expanded new edition of a classic volume in the field. It covers all aspects of liposome technology, including liposome preparation and analysis, drug entrapment, and techniques used for in vivo and in vitro evaluation of liposomes. Leading authorities have contributed 70 chapters to create what is destined to [...]

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Janssen Supplies DOXIL to Support Endocyte Phase 3 PROCEED Trial Pharmaceutical Business Review

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Janssen supplies DOXIL to support Endocyte Phase 3 PROCEED trialPharmaceutical Business ReviewJanssen Products is supplying DOXIL (doxorubicin HCl liposome injection) to support Endocyte's ongoing Phase 3 PROCEED trial. The randomized, double-blind clinical trial is designed for evaluating Endocyte's vintafolide drug in combination with DOXIL ...Endocyte secures Doxil supply from Janssen to support ongoing phase III [...]

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Applied Cell and Molecular Biology for Engineers

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A Guide to the Fundamentals and Latest Concepts of Molecular and Cell Biology Bridging the gap between biology and engineering, Applied Cell and Molecular Biology for Engineers uses clear, straightforward language to introduce you to the cutting-edge concepts of molecular and cell biology. Written by an international team of engineers and life scientists, this vital [...]

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Biotech Receives $32.5 Million for Cancer Research Lexology Registration

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Biotech receives $32.5 million for cancer researchLexology (registration)The biopharmaceutical reports that the funds will be used to support a Phase 3 clinical study of its CPX-351 Liposome Injection, an “experimental therapy for secondary acute myeloid leukemia.” According to Celator, the Phase 3 clinical study is ... Read the full story: Biotech receives $32.5 million for [...]

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Fatty Acids (Nutrition and Health)

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Leading academic and biomedical researchers comprehensively review the status of essential fatty acids (EFA) in nutrition, medicine, psychology, and pharmacology. Topics range from a discussion of EFA basic mechanisms to their effects on individual psychiatry and behavior, and include extensive coverage of pathology, DHA in CNS development, and phospholipid and fatty acid composition and metabolism. [...]

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Receptors: Models for Binding, Trafficking, and Signaling

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Receptors: Models for Binding, Trafficking, and Signaling bridges the gap between chemical engineering and cell biology by lucidly and practically demonstrating how a mathematical modeling approach combined with quantitative experiments can provide enhanced understanding of cell phenomena involving receptor/ligand interactions. In stressing the need for a quantitative understanding of how receptor-mediated cell functions depend on [...]

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Research and Markets Global RNAi Drug Delivery Market 20142018 With ... Business Wire Press Release

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Research and Markets: Global RNAi Drug Delivery Market 2014-2018 with ...Business Wire (press release)For example, Bio-Path Holdings Inc. developed systemic delivery of antisense, small interfering RNA, and hydrophobic small molecules for treatment of various diseases using its neutral lipid drug delivery technology (neutral liposome). Similarly ... and more& » Read the full story: Research and [...]

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